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Transfermarkt compiled the data on players in England's top-flight league to determine who would carry the biggest price tag.
And Salah, Kane, Mane and De Bruyne came out on top of the pile, with the four players being valued at a whopping £108m each.
Bruno Fernandes, who has been in scintillating form since his arrival at Manchester United in January, also managed to crack the top 10.
The 26-year-old Portuguese midfielder has seen his stock rise to an impressive £81m, putting him well clear of fellow United teammates Marcus Rashford (£72m) and Paul Pogba (£58.5m).
Other players that managed to make the top 30 included Chelsea midfielder N'Golo Kante, Manchester City starlet Phil Foden and Tottenham forward Son Heung-min.
Posted below are the 25 most valuable Premier League players, according to Transfermarkt.
30. Declan Rice (West Ham United): £49.5m
29. James Maddison (Leicester City): £49.5m
28. Anthony Martial (Manchester United): £49.5m
27. Ederson (Manchester City): £50.4m
26. Gabriel Jesus (Manchester City): £54m
25. Fabinho (Liverpool): £54m
24. Phil Foden (Manchester City): £54m
23. Aymeric Laporte (Manchester City): £54m
22. Richarlison (Everton): £54m
21. Christian Pulisic (Chelsea): £54m
20. Gabriel Jesus (Manchester City): £54m
19. N'Golo Kante (Chelsea): £54m
18. Rodri (Manchester City): £57.6m
17. Paul Pogba (Manchester United): £58.5m
16. Bernardo Silva (Manchester City): £63m
15. Timo Werner (Chelsea): £63m
14. Roberto Firmino (Liverpool): £64.8m
13. Andy Robertson (Liverpool): £67.5m
12. Virgil van Dijk (Liverpool): £72m
11. Marcus Rashford (Manchester United): £72m
10. Alisson (Liverpool): £72m
9. Kai Havertz (Chelsea): £72.9m
8. Son Heung-min (Tottenham Hotspur): £81m
7. Bruno Fernandes (Manchester United): £81m
6. Trent Alexander-Arnold (Liverpool): £99m
5. Raheem Sterling (Manchester City): £99m
4. Kevin De Bruyne (Manchester City): £108m
3. Sadio Mane (Liverpool): £108m
2. Harry Kane (Tottenham Hotspur): £108m
1. Mohamed Salah (Liverpool): £108m
Featured Image Credit: PA
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