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Reguilon was taking part in a video feature with ProDirect Soccer, where the Spaniard was guessing players based on their FIFA 22 card ratings. It was in this interview where he singled out the Manchester City duo.
"Against City but not one player. Walker and Mahrez...too difficult," he admitted in quotes published by football.london.
Walker has featured 13 times across all competitions so far for Man City, and scored in a 5-1 thrashing of Club Brugge.
Mahrez has enjoyed a superb season for Pep Guardiola's side, scoring 8 goals in his 15 appearances across all competitions, most recently the net in that same 5-1 win over Brugge.
His form is especially impressive in this season's Champions League, finding the net 4 times in 4 outings in Europe's premier cup competition.
Conte's first league match in charge ended in a goalless draw away at Everton on 7th November.