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The 32-year-old Poland captain was in scintillating form last season as he helped fire the German side to a treble.
And Lewandowski, who is widely regarded as one of the best strikers in the world, was also the favourite to win the Ballon d'Or before France Football cancelled the 2020 award.
The former Borussia Dortmund star has faced his fair share of quality opposition in the Bundesliga, Champions League and on the international stage, but he picked out Ramos as the most formidable opponent he has faced.
"The toughest opponent? There are plenty of good defenders, but it has always been great to have duels against Sergio Ramos," Lewandowski told Goal.
"I was always happy to be able to compete with him."
Lewandowski has previously revealed that Ramos and Cristiano Ronaldo wanted him to sign for Madrid after Los Blancos defeated Bayern in the Champions League quarter-final in April 2017.
The Bayern star said at the time: "Yes [Ronaldo and Ramos asked me to join Real].
"You can go to the Spanish league or to one in another country, another great club. But for me, it was not the most important thing.
"Where I am, I have been able to reach my maximum level and I want to continue doing well.
"I am at one of the best clubs in the world and I know I can be happy here. We are at a very high level, from the playing squad to the sporting facilities.
"It's all much easier when playing for a club like this."
Featured Image Credit: PA
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