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The Red Devils opened the scoring at Old Trafford on Thursday in the first-leg Europa League semi-final clash.
Pogba combined expertly well with Edinson Cavani, who played the ball through to Bruno Fernandes before the United star fired his side 1-0 up in the ninth minute.
However, United's lead was shattered only minutes later after Roma received a controversial penalty decision in their favour.
Pogba slid in for the ball with Rick Karsdorp, but the Roma right-back managed to clip the United star's arm with the ball.
Roma skipper Lorenzo Pellegrini stepped up for the subsequent penalty and smashed the ball past David de Gea.
But United fans took to social media to defend Pogba and questioned how Roma were awarded a penalty.
"They need to change this handball rule, what else can he do on a wet surface sliding in," one fan posted.
Someone else tweeted: "What is the point in VAR if there is no consistency in handball decisions. Where is he [supposed] to put his hands when he's sliding like that?"
A third Twitter user wrote: "Football is actually ruined. How the hell is that handball?"
And a fourth added: "These handball rules that [sic] are different game by game."
Roma stunned United before half-time by taking the lead at Old Trafford through former Manchester City striker Edin Dzeko.
Former United player Henrikh Mkhitaryan picked out Pellegrini in the box with an inch-perfect pass.
Pellegrini fired a low cross to an onrushing Dzeko, who slammed the ball past a helpless De Gea.
Roma lead 2-1 against United at Old Trafford going into half-time.
Featured Image Credit: PA
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