The 32-year-old hasn't played football for over 10 months under Mikel Arteta who has frozen him out of his squad in the Premier League and Europa League.
His departure has split Arsenal fans, but Mustafi has stayed loyal to his fellow German compatriot - posting an emotional message on social media.
He tweeted: "Bro, you have been the most unselfish player on and off the pitch, I have ever shared the dressing room with.
"You will be always remembered as the #AssistKing. Unfortunately we as a team haven't been able to assist you when you needed us the most. All the best."
Bro, you have been the most unselfish player on and off the pitch, I have ever shared the dressing room with. You will be always remembered as the #AssistKing. Unfortunately we as a team haven't been able to assist you when you needed us the most. All the best :heart: #SM20 pic.twitter.com/gEfl6AWzZj
- Shkodran Mustafi (@MustafiOfficial) January 18, 2021
Mustafi's heartfelt tribute to Ozil got fans talking with some Arsenal supporters thinking that the defender aimed a thinly-veiled dig at the club.
Can't get mad at Mustafi no matter what he does now, I'm still too grateful to him for rejection the new contract offer. My center back!:joy::joy: pic.twitter.com/j3eJbUT3pd
- Jean-Michail Jefferson (@Klarence_o) January 18, 2021
Shkodran Mustafi just book a 6 months vacation on full pay.
- Positively Arteta sceptic (Blackburn George) (@arseblagger) January 18, 2021
Imagine getting worked up over Mustafi's defense of his friend, his countryman and his world cup teammate.
- You Are My Arsenal (@YouAreMyArsenal) January 18, 2021
They're doing 'you are next' on Mustafi's tweet like mans didn't reject their offer to extend when they brought it forward.. circus club
- Señora Acero :muscle: (@Holawhunmee) January 18, 2021
Y'all think Mustafi didn't know the post will attract negative comments??
Mans leaving now or in six months time, so the joke is on you if you insult him..
- Oluwakayode Adeyemi :zap: (@KvngKortez) January 18, 2021
One joked: "Mustafi with the best defending he's done in his whole career."
A second tweeted: "Mustafi sending shots at my club."
A third added: "See people criticising this tweet. Mustafi has been treated very poorly from a large portion of our fanbase. 6 months left on his contract with little chance of featuring too often. Don't think he'll lose any sleep that he's upset some people."
Ozil's seven-and-a-half year spell at the Emirates has come to an end as the World Cup winner fulfills a life-long dream of playing football in Turkey.
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