Varane started for France against Spain in the UEFA Nations League final, but did not last the half.
He appeared to suffer a suspected hamstring injury before the break, with Didier Deschamps taking no risks - immediately subbing him off.
Varane's injury scare is not good news for Man United boss Ole Gunnar Solskjaer, who is already under pressure and preparing his side for a brutal run of fixtures.
Rest up, @RaphaelVarane :pray:
#MUFC ' #NationsLeague https://t.co/fe7W78lQWl
- Manchester United (@ManUtd) October 10, 2021
Solskjaer is also currently without captain Harry Maguire, who was ruled out against Everton.
The Red Devils resume their Premier League campaign against Leicester City on October 16, before facing Tottenham, Liverpool and Manchester City.
They also have crucial Champions League matches against Atalanta and Villarreal, not to mention fixtures against Chelsea and Arsenal in the league next month.
Varane limping off for France got Man United fans talking online.
United are relying solely on Lindelof and Bailly for this run :sob::sob::sob: pic.twitter.com/qfKicxCMQ0
- Roy (@_CFCRoy) October 10, 2021
Varane off injured....even a couple of weeks out is a big blow with Maguire out too
- Mark Goldbridge (@markgoldbridge) October 10, 2021
Toughest run of the season coming up without Maguire and Varane pic.twitter.com/G1r1KYIpSU
- Jordan (@FourFourJordan) October 10, 2021
Varane going off injured. I hate international breaks. Potentially no Maguire or Varane for our tough run coming up now..
- Jack (@UtdJackkkk) October 10, 2021
Victor Lindelof was drafted into the starting XI against Everton, with the Swede potentially in line to keep his place against Leicester.
Eric Bailly, who has yet to play in the league this season, could replace Varane.
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