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The Argentine striker became the club's record scorer and lifted five Premier League titles, six League Cups and an FA Cup with City.
Aguero, who has been heavily linked with Barcelona, came off the bench in his final Premier League appearance and scored a second-half brace in City's 5-0 demolition of Everton.
Speaking after the match, Guardiola hailed the Argentina international as a "special person" and insisted that City "cannot replace him."
The City boss told Sky Sports: "He's a special person for all of us.
"He's so nice. He helped me a lot, he's so good. We cannot replace him, we cannot.
"There have been many players at this club, like Joe Hart and David Silva, who have helped us to be this club -- what it is.
"We helped his legacy and he showed his quality in 20 minutes."
City dethroned Liverpool from the top of English football as they captured the Premier League title this season.
Aguero could end his incredible City career on an even higher note should Guardiola's men finally capture the Champions League title.
Kyle Walker has admitted that his City teammates want to ensure Aguero has the perfect send-off by securing a Champions League winners' medal for him.
The 30-year-old City right-back said: "Kun is a legend.
"There's no other way to describe the man, for what he has done for this club and the Premier League. Not many people come into his bracket.
"Hopefully, we can send him off with a Champions League medal around his neck, something I am sure he has dreamt about his whole life."
Featured Image Credit: Football Daily/Twitter
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