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The Red Devils have quite the fixture pile-up to contend with, with the rearranged Liverpool fixture taking place on Thursday - just 48 hours after tonight's 6pm kick-off at Old Trafford.
The original game was postponed due to United supporters storming their stadium in protest against the Glazer family.
As a result, Solskjaer has made ten changes and rested all of his big guns - including Luke Shaw, Paul Pogba, Harry Maguire, Bruno Fernandes and Marcus Rashford.
David De Gea starts in goal, with Brandon Williams, Eric Bailly, Axel Tuanzebe and Alex Telles across the back.
Nemanja Matic and Donny van de Beek anchor the midfield, giving the base for Juan Mata and youngsters Amad Diallo and Anthony Elanga.
Mason Greenwood, scorer of United's second against Aston Villa on Sunday, keeps his place in the starting XI and plays up top on his own.
FPL enthusiasts won't be best pleased, but the real fume comes from Liverpool supporters given they are tussling with Leicester for the final Champions League spot and were hoping for a favour from their North-West rivals:
As it stands, last season's champions are in sixth place and heading towards the Europa League next season. With four games remaining, the Reds are on 57 points - five behind Leicester in fourth.
Speaking in his press conference, Solskjaer felt he had to make wholesale changes due to his side playing three times in five days.
"Talking about integrity in the league and stuff, don't blame me when I have to make changes because I have to," the Norwegian said.
"It's not safe for them to play all four so I have to prioritise.
"I wish I could have said 'Let's go full out in all the games' but it's impossible. That's the hard bit for me, knowing if I do play this 11 on Tuesday and then again on Thursday it's impossible. I run too much of a risk in injuring them."
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