To make sure you never miss out on your favourite NEW stories, we're happy to send you some reminders
Click 'OK' then 'Allow' to enable notifications
Avid marijuana enthusiast Tyson was smoking joint to begin with but then followed it up by casually chewing through around four or five grams of mushrooms he was handed by 'imPaulsive' co-host Mike Majlak.
It was literally five minutes into the podcast and 'Iron Mike' shoved in far more than the usual intake for your average joe and didn't even stop to drink some water.
When discussion turned to the potential further legality for mushrooms, Tyson said he believes "it's going to be the best thing in the 21st century and taking them "helps me be a better me".
He then confirmed he trains after taking mushrooms and may have taken some a few days before he returned to the ring for the first time in 15 years in an exhibition bout with Roy Jones Jr last month.
The 54-year-old then begun to discuss other psychedelic drugs such as 'DMT' and 'Changa' and his experiences dabbling into those substances.
In fact, he's gone on record to state that it was his consuming of a psychedelic 'named 'The Toad', extracted from a rare species of toad from the Sonoran desert in America, that led to his incredible weight loss and subsequent boxing comeback.
"I took the medicine and the medicine told me to get into shape," Tyson said during the weigh-in ahead of his Staples Center exhibition.
"It really blew my mind. It told me to come back and start getting in shape."
It's said that the drug, which is far more powerful than DMT, causes a religious-like trip where users feel their state of consciousness altered in the space of five minutes.
On the podcast, Tyson described how taking these drugs made him feel, likening it to seeing "the sun open up".
It should be noted that the whole conversation wasn't just about Tyson experimenting with drugs, he talked about his upbringing and how he was arrested 40 times before he was 12 years of age.
His Hall of Fame boxing career was of course a key topic but the two-time world heavyweight champion told Paul exactly what he thought regarding his transition into the squared circle.
'The Maverick' takes on Floyd Mayweather in a "super exhibition fight" in February and when asked for his prediction right in front of Paul, Tyson said: "Floyd's gonna beat his f**kin' a**.
"But it's gonna be good! It's gonna be good, he's gonna fight back though!"