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The talkSPORT pundit doesn't rate Man United's options up front compared to their domestic rivals.
He continued by hailing Liverpool's attacking trident of Mohamed Salah, Sadio Mane and Roberto Firmino.
He believes Jurgen Klopp's attack is the best in the league, followed by Manchester City AND Tottenham before mentioning Ole Gunnar Solskjaer's side.
He said: "Liverpool have the best front-three in the Premier League - Sadio Mane, Roberto Firmino and Mohamed Salah.
"That's better than Man United's, for me.
"Not based on last season, just based on talent and what they can produce when they're at their best."
THE WAIT IS FINALLY OVER. @ManUtd :red_circle: pic.twitter.com/k4rEbNYmdg
- Jadon Sancho (@Sanchooo10) July 24, 2021
The former Spurs man added: "I'd also argue Man City; if they line up with Phil Foden, Riyad Mahrez and Kevin De Bruyne as a false nine.
"That's probably better than Manchester United's, too."
With the departure of Sergio Aguero, O'Hara reckons Pep Guardiola needs to sign a striker this summer ahead of the new season.
"City do need to sign a new striker, but KDB is brilliant when he plays there," O'Hara said.
"If it's a choice between Gabriel Jesus and Cavani, you'd have to say Cavani, but if you're talking Foden or Rashford, you'd say Foden."
On United's attack vs. Spurs' attack, he explained: "In my opinion, I think Spurs' front-three at their best is still better than that Manchester United front-three."
Host Andy Goldstein asked: "So what, Son, Kane and Moura is better than Rashford, Cavani and Sancho?"
O'Hara replied: "Yeah, Son is better than Rashford, Kane is better than Cavani, and OK Moura is not better than Sancho...
"But Moura had a great finish to last season and does produce at the top level."
Who has the best attack in England's top flight? Let us know what you think.
Featured Image Credit: PA
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