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The Red Devils had a Edinson Cavani strike controversially ruled out in the first half after Chris Kavanagh went to the VAR screen and deemed that Scott McTominay's brush of a hand was a foul on Heung-Min Son because it "wasn't part of his natural running movement and was careless."
Minutes later, after being on the turf, Son put Spurs 1-0 up - with United furious that they went in at half-time a goal down.
But Fred equalised after a fine, flowing team move before a second goal from Cavani - a sublime header following a delightful Mason Greenwood cross - completed another turnaround on the road for United in the 79th minute.
After his wonderful assist, substitute Greenwood rounded off the win with a right-footed shot in stoppage time.
The win means United are now 11 points behind league leaders Manchester City after they lost 2-1 at home to Leeds United at the Etihad Stadium yesterday.
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