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Diogo Jota, Roberto Firmino (x2) and Mohamed Salah secured a famous Liverpool win at Old Trafford as they climb to fifth place in the Premier League.
Marcus Rashford and Bruno Fernandes scored for the hosts as Ole Gunnar Solskjaer's side remain in second place - despite losing back-to-back league matches this week.
Fernandes opened the scoring in the 10th minute after his deflected strike found the back of the net.
But Jota cancelled out his effort with a flick from Nathaniel Phillips' shot across the box.
Firmino put his side in the lead in first half injury time, scoring a bullet header at the back post.
Rashford pulled one back with Salah completing the scoring in the 90th minute.
Jurgen Klopp's side move to fifth place with 60 points on the board, four points behind fourth-placed Chelsea who face Leicester City next.
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