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The six-time Ballon d'Or winner is leaving the Blaugrana after a 21-year association and is poised to join Paris Saint-Germain in a stunning free transfer.
Messi departs the Nou Camp as the club's greatest ever player and record goalscorer, with 672 goals in 778 appearances.
In total, he scored against 81 different teams in various competitions - with just eight managing to stop him from finding the net.
A year ago it was ten but Messi found the net against Napoli in the Champions League in August 2020 before he converted a penalty against Cadiz in February.
Undoubtedly, the biggest Messi hasn't scored against is Inter Milan, who have kept him goalless in four matches over the years.
He drew a blank three times in the 2009/10 Champions League season when Inter went onto win the competition under Jose Mourinho, with the fourth coming in October 2019.
Interestingly, he has also had a tough time against Russian side Rubin Kazan, who he has played against four times in the Champions League without scoring.
Benfica and Xerez have come up against him twice and thwarted him, while Al-Sadd of Qatar, Real Murcia, Gramenet and Udinese also have the honour of stopping Messi from scoring in the one game they played against him.
Inter Milan (Italy)
Rubin Kazan (Russia)
Al Sadd (Qatar)
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