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The technology is widely used across the board now and continues to be a source of controversy for the way it is being used by referees.
There's still strong opposition from football fans who have seen plenty of marginal offsides result in goals being disallowed.
Players are also not onboard, with Cavani the latest high-profile player to express his frustration with VAR and the impact it has on celebrations.
The Uruguayan striker, who recently signed a new contract at United, saw a strike chalked off just last month.
Cavani had the ball in the net against Spurs but his goal was disallowed following a long VAR review that saw Chris Kavanagh head over to the screen and decide that Scott McTominay had fouled Heung-Min Son in the build-up.
He did end up getting on the scoresheet in a 3-1 one win but did not hide his disdain towards VAR.
"VAR takes away the charm and the essence of football," the 33-year-old told South American outlet DosDePunta.
"You don't know why a referee awards a penalty against you or rules you offside - or even how it works.
"It is difficult. You score a goal and then have to wait two minutes before you can celebrate.
"Or, even worse, you celebrate then they tell you it has been ruled out because your fingernail or your hair was in an offside position.
"Or else because one of your team-mates committed a minor foul that nobody noticed - 14 passes before you put the ball in the net.
"Us players don't count when things like this are brought in. It's a case of 'Play and keep your mouth shut - you earn lots of money.'
"Football is becoming a slog for us, even if there is some passion as well. You need to keep a cool head to put up with this routine for a long time."
The former Paris Saint-Germain also offered some strong opinions on the proposed European Super League that collapsed following monumental criticism from fans, pundits, government ministers and governing bodies.
Cavani, as expected, is completely against the idea of a Super League and believes it would stop "average clubs" from dreaming big.
He added: "When the Super League came around I told myself: 'That can't be possible - if it happens, what can we expect next?'
"I don't share its ideas at all. I am not in agreement with it.
"You mustn't deprive more modest teams the chance of playing in the Champions League.
"Or stop average clubs from dreaming of competing with the bigger ones, and having a place among the elite.
"You can't deny fans of these clubs the chance to have this experience."
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