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With just one point against newly-promoted side Norwich City, the Magpies sit 19th in the table and are yet to taste victory so far this season.
Meanwhile, the Whites are also winless, having picked up just two points from their first four games and are in 17th place.
Interestingly, Newcastle boss Steve Bruce has brushed off rumours questioning his position as head coach, however, another defeat should increase the pressure already on his shoulders.
Ahead of the game, our tipster Robert Mann takes a look at some of best bets from Newcastle vs Leeds United to get your teeth stuck into it.
Newcastle United are 2/1 to win, with Leeds United priced at 6/5 to come away with the victory. A draw is priced at 11/4.
Prediction: 1-2 (15/2)
Match Result: Leeds United (6/5)
Bruce’s men are in desperate need of a confidence-boosting win, however, with doubts over the fitness of star striker Callum Wilson, it may be unlikely to come against Friday’s visitors.
Marcelo Bielsa’s side also completed the double over Newcastle last season, winning 5-2 at Elland Road and 2-1 at St James’ Park, and we're backing them to come away with all three points again.
Full-Time Result and U/O Goals: Leeds United and Over 2.5 Goals (11/5)
Newcastle have the worst defensive record in the division to date, conceding 12 goals in four games, with Leeds not doing much better having conceded 11.
The previous 18 Premier League meetings between these sides have produced a staggering 62 goals at an average of over three goals per game.
Anytime Goalscorer: Jamaal Lascelles (14/1)
Leeds had the worst defensive record from set-pieces last season, conceding 15 times - and they have endured the same struggles again this term.
One asset the Magpies do have is height and Jamaal Lascelles - standing at 6ft 2in - will be relishing the chance of taking on a fragile opposition defence.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
🎙️ "There's only four games played" Marcelo chats to the press ahead of tomorrow's trip to Newcastle https://t.co/8afV10R0Cv— Leeds United (@LUFC) September 16, 2021