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Ole Gunnar Solskjaer’s side have made a good start to the campaign, collecting seven points from their opening three matches.
On the other hand, Newcastle’s fortunes are different to the Red Devils and manager Steve Bruce will be desperate for a result after a return of one point from three games.
The match is expected to mark the second debut of Ronaldo who is set don his famous number seven shirt for the first time since 2009, but how will he fair in the Premier League 12 years later?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Manchester United vs Newcastle United to get your teeth stuck into.
Manchester United are 1/6 to win, with Newcastle United priced at 14/1 to come away with the victory. A draw is priced at 13/2.
Prediction: 0-1 (11/2)
To Win Both Halves: Manchester United (11/8)
Manchester United have won two of their first three fixtures and have done so by winning both halves, most notably when thrashing Leeds United 5-1 in the opening game of the season.
First Goalscorer: Cristiano Ronaldo (9/4)
Having scored twice for Portugal last week, Ronaldo became the highest goalscorer in the history of international football and we're backing him to continue that form at Old Trafford.
As mentioned, the Newcastle defence have leaked eight goals in their first three matches and Ronaldo should be able to manipulate that form, too.
Headed Shot On Target: Cristiano Ronaldo (6/4)
As you might expect of a man who has scored a staggering 785 goals for clubs and country, Ronaldo can find the net in many different ways - especially with his head.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Ronaldo has trained alongside his new teammates this week, and the Portuguese phenomenon is expected to go straight into the starting line-up on Saturday afternoon as a centre forward.
Callum Wilson picked up a thigh problem in the draw with Southampton before the international break and is set to miss out, meaning that Joelinton could feature alongside Allan Saint-Maximin as part of a front two.
📺 Steve Bruce speaks to the media ahead of #MUNNEW.— Newcastle United FC (@NUFC) September 10, 2021
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