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In this particular meeting, the Gunners have suffered as of late and the history books suggest they usually struggle against the Citizens.
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Manchester City vs Arsenal to get your teeth stuck into.
Manchester City are 2/9 to win, with Arsenal priced at 11/1 to come away with the victory. A draw is priced at 5/1.
Prediction: 3-0 (13/2)
Half-Time/Full-Time: Manchester City (8/11)
For the first time in Arsenal's history, the club lost their first two league games - including a shock defeat to newly-promoted Brentford - and have failed to score so far, with injuries plaguing the squad.
Manchester City, meanwhile, thrashed Norwich City at the Etihad last time out and, with City at home again, it would come as no surprise to see them dominate in both halves against the Gunners.
Win to Nil: Manchester City (1/1)
Arsenal have not only gone two league games without winning, but have also not looked likely to find the net, either.
Guardiola's men have kept seven clean sheets in the previous ten encounters between the pair, while at home they have won to nil in two of their last three clashes.
Anytime Goalscorer: Raheem Sterling (7/5)
Raheem Sterling's record against the Gunners is too hard to ignore and he looks like great value in the anytime goalscorer market.
Interestingly, in the last eight meetings between the two clubs, Sterling has found the back of the net five times and he should have an easy time against a vulnerable Arsenal defence, especially with Ben White still out.
Odds are correct at the time of publication and are, as always, subject to change. Please gamble responsibly. For more information visit: https://www.begambleaware.org.
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