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It will be the first time that Bielsa and Benitez - two of the finest coaches of their generation - cross swords in English football for the first time, but who will come out on top?
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Leeds United vs Everton to get your teeth stuck into.
Leeds United are 6/5 to win, with Everton priced at 2/1 to come away with the victory. A draw is priced at 13/5.
Prediction: 1-2 (9/1)
Match result: Everton (2/1)
Following their abysmal display away at Old Trafford, Leeds will hope that they can convert their home advantage into a vital three points.
Everton played some exciting football in the second half of their season opener against Southampton and, although this may be a cagey affair, we're backing the Toffees to come out on top like they did last season.
Under/Over Goals: Under 2.5 (6/5)
Fixtures between these two sides in the Premier League are often low-scoring games, with five of the last seven matches between them seeing under 2.5 goals scored.
Despite Leeds looking vulnerable defensively against the Red Devils, Bielsa's men are a different breed at home and should have a much tighter back line going into this afternoon's game.
First Goalscorer: Patrick Bamford (4/1)
Patrick Bamford had a rough time in terms of chances last weekend, however, after signing a new five-year contract on Friday, it may just give him a new lease of life in front of goal.
The 27-year-old was the Premier League's fourth highest goalscorer last term - 17 goals in total - and we're backing him to get off the mark here at attractive odds of 4/1.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
In a big blow for Bielsa's side, defensive stalwart Diego Llorente will be unavailable until the end of the month.
🎙️ "His teams are efficient, strong and hard to beat" Marcelo looks ahead to our clash with Rafa Benitez's Everton https://t.co/ia8VHJIUsw— Leeds United (@LUFC) August 19, 2021
Other doubts include Andre Gomes and Jean-Phillipe Gbamin, while Jarrad Branthwaite is set to miss out due to injury.
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