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The Reds won their first Premier League title last season and that came with Roberto Firmino up front.
But FourFourTwo's rankings have seen Firmino replaced by summer signing Jota, who has scored nine goals since arriving from Wolves in the summer.
Firmino's omission can be considered harsh as the Brazilian allows Salah and Mane to enjoy more freedom in the final third.
Tottenham Hotspur's front three come in second and Manchester City's are in third.
Manchester United place outside the top five however with Chelsea and Everton above them in fourth and fifth respectively.
Check out the entire list below.
20. Sheffield United (Rhian Brewster, David McGoldrick and Olly Burke)
19. Brighton & Hove Albion (Neal Maupay, Aaron Connolly and Leandro Trossard)
18. West Bromwich Albion (Matheus Pereira, Grady Diangana and Karlan Grant)
17. Burnley (Dwight McNeil, Chris Wood and Jay Rodriguez)
16. Fulham (Aleksandar Mitrovic, Ademola Lookman and Ivan Cavaleiro)
15. Crystal Palace (Michy Batshuayi, Wilfried Zaha and Andros Townsend)
14. Newcastle United (Callum Wilson, Allan Saint-Maximin and Ryan Fraser)
13. Leeds United (Helder Costa, Patrick Bamford and Rodrigo)
12. Southampton (Danny Ings, Che Adams and Nathan Redmond)
11. West Ham United (Michail Antonio, Jarrod Bowen and Said Benrahma)
10. Arsenal (Nicolas Pepe, Bukayo Saka and Pierre-Emerick Aubameyang)
9. Aston Villa (Trezeguet, Ollie Watkins and Jack Grealish)
8. Leicester City (Jamie Vardy, Harvey Barnes and Cengiz Under)
7. Wolverhampton Wanderers (Pedro Neto, Raul Jimenez and Adama Traore)
6. Manchester United (Mason Greenwood, Marcus Rashford and Anthony Martial)
5. Everton (James Rodriguez, Dominic Calvert-Lewin and Richarlison)
4. Chelsea (Christian Pulisic, Timo Werner and Hakim Ziyech)
3. Manchester City (Raheem Sterling, Sergio Aguero and Riyad Mahrez)
2. Tottenham Hotspur (Heung-min Son, Harry Kane and Gareth Bale)
1. Liverpool (Sadio Mane, Mohamed Salah and Diogo Jota)
But manager Jurgen Klopp insists there is no seletion headache when choosing between the pair.
"We would not even be in the Champions League if Bobby Firmino wasn't with us, and immediately I have to explain why he's not in the team. He will be in the team," he told Sky Sports after Jota's hat-trick against Atalanta last month.
"For a lot of people in the world, if you asked them what makes Liverpool on Sunday special, they would say the way Bobby Firmino is playing.
"It's important for us that we have more than 11, and tonight Diogo used his shape in an incredible way and played a super, super game.
"But that says nothing about Bobby and has nothing to do with causing me headaches. I'm more than happy that the boys played like that tonight."
Who do you think has the best front three in the Premier League?
Featured Image Credit: PA Images
Topics: Manchester City, Spurs, Liverpool, Hakim Ziyech, Aston Villa, Leicester City, Chelsea, Tottenham Hotspur, Manchester United, Man U, Adama Traore, Mason Greenwood, Sheffield United, Diogo Jota, Southampton, Man utd, Premier League, Everton, Marcus Rashford, West Brom, West Ham United, Leeds United, Man City, Arsenal, Wolves, Sadio Mane, Burnley, Mo Salah, Fulham, Newcastle United, Harry Kane, Raheem Sterling, Brighton, Crystal Palace
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