Henry had two spells with the Gunners, between 1999 and 2007 as well as spending half a season on loan in 2012.
It goes without saying he doesn't care much for Spurs... that didn't make its way to Amazon Prime Sports' studio on Thursday.
The 44-year-old was asked about Spurs' clash with Rennes by the host before replying: "Sorry who? I don't know them."
Henry's two co-hosts start to laugh as his expression stays blank.
Fans have reacted to the video and they think it could already be one of the season's funniest moments.
Henry is bigger than Tottenham. Fact. No debate https://t.co/UgTxD4aucr
- Paul (@KingPaul_AFC) September 16, 2021
MY FREAKIN LEGEND I LOVE HIM SO MUCH:joy::joy::joy: https://t.co/9YEGVr3JHs
- Mohammad Al-Khalil (@mo__khalil) September 16, 2021
The way he keeps a straight face :sob::sob::sob::sob: https://t.co/HGRnoARhYq
- Hale End's (@argh_man) September 17, 2021
Henry's face whenever he delivers a line like this is too good :joy: https://t.co/wW7LzdFjSR
- casey (@casey_baughan) September 16, 2021
Nuno Espirito Santos' side couldn't start Group G with a win and came from behind to draw 2-2 with Rennes.
Loic Bade turned into his own net in the 11th minute to give Spurs the lead before Flavien Tait equalised just 12 minutes later.
Gaetan Laborde put the home side ahead with less than 20 minutes to go, only for Pierre-Emile Hojbjerg to neatly level the score.
Spurs lost 3-0 to Crystal Palace on Saturday afternoon and Santo made seven changes to his side.
"It was not perfect, but we showed a lot of character and belief to change the result after we conceded," Nuno said of his changed line-up per The National.
"They are a hard team to play and it is not easy to analyse the game. We had a lot of players out of position."
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