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Cavani and Pogba both came off the bench in the second half during the 2-2 draw, with Cavani assisting Bruno Fernandes.
United missed a chance to go second with the draw and legendary midfielder Scholes thought his former side improved after making substitutions.
"United were better when they made the subs. I thought they left the best players on the bench," he told BT Sport per Daily Mail.
"Pogba was good when he came on, Cavani too. Greenwood is a good player but didn't get on. I don't think United should leave these players out.
"When Greenwood, Martial and Rashford play with Fernandes in behind nobody can handle it. It's great to have Cavani coming on and there are some games he can play in."
A draw isn't a poor result for either side in isolation, but Scholes thinks the result will benefit current league leaders Liverpool most.
"There are 12, 13 ,14 players that can do the business but there will be players like Dan James against Leeds last week. Can they win the league? I don't know. I think they can challenge but Liverpool are too good for everyone else.
"It's going to be difficult for teams to get near Liverpool so it's a great result for them today."
United took the lead through Marcus Rashford, who slotted past Kasper Schmeichel thanks to a Fernandes pass.
Their lead wouldn't last however as Harvey Barnes rifled home an equaliser just past the half hour mark.
Rashford had a glorious chance to double his tally in the second half but Schmeichel produced a strong hand.
Anthony Martial had the ball in the back of the net but VAR denied the Frenchman.
Fernandes got on the scoresheet 11 minutes from time and United thought they had taken all three points.
Another game, another goal for Bruno Fernandes! :fire:- Football on BT Sport (@btsportfootball) December 26, 2020
Edinson Cavani with a HUGE impact from the bench to create the assist! pic.twitter.com/6lwaGioMYn
But in the 85th minute, Jamie Vardy's shot hit Axel Tuanzebe and the ball bounced beyond David de Gea's grasp.
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Featured Image Credit: BT Sport & PA Images
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