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The Portuguese coach - and self-proclaimed 'The Special One' - leaves the north London club seventh in the Premier League and just six days before the Carabao Cup final against Manchester City on Sunday.
Their Europa League campaign also ended in defeat at the round of 16 stage. Holding a 2-0 first-leg lead over Dinamo Zagreb, Spurs were stunned by a second leg comeback in Croatia as they crashed out by a 3-2 aggregate scoreline.
Mourinho replaced Mauricio Pochettino in December 2019 eventually guiding the team to a sixth-placed finish and Europa League football.
The 2020/21 season began in a much more positive fashion with the side even topping the Premier League table in the early months.
But a sharp downturn in form has seen Daniel Levy pull the trigger leaving him searching for Mourinho's successor.
Julian Nagelsmann has been installed as the clear favourite to become their next permanent manager.
The 33-year-old German is the market leader, after being cut from 14/1 into 7/2 at the time of writing.
Oddschecker spokesperson Callum Wilson commented: "It's not been a quiet 48 hours in the football world, and the latest bombshell of Jose Mourinho being sacked has seen punters flock to the next Spurs manager market.
"Bookies have cemented a clear favourite in RB Leipzig manager Julian Nagelsmann at 4/1, with some bookies going as short as 5/2."
* 20/1 bar. Odds taken from Betfair and correct at time of publication
Daniel Levy has taken drastic action over the club's disappointing form - just days before Sunday's Carabao Cup final against Manchester City.
Levy wrote in an official statement on Tottenham's website: "Jose and his coaching staff have been with us through some of our most challenging times as a Club.
The Club can today announce that Jose Mourinho and his coaching staff Joao Sacramento, Nuno Santos, Carlos Lalin and Giovanni Cerra have been relieved of their duties.#THFC :white_circle: #COYS
- Tottenham Hotspur (@SpursOfficial) April 19, 2021
"Jose is a true professional who showed enormous resilience during the pandemic.
"On a personal level, I have enjoyed working with him and regret that things have not worked out as we both had envisaged.
"He will always be welcome here and we should like to thank him and his coaching staff for their contribution."
With the Portuguese now gone, it's believed that first-team coaches Ryan Mason and Chris Powell will take charge for the remainder of the season.
But who will get the job on a permanent basis?
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