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In a run that stretches all the way back to 1975, Portugal have beaten France just once in their last 13 games against their European counterparts.
Les Bleus remain at the top of Group F, despite being held to a 1-1 draw by Hungary on matchday two, while Portugal currently find themselves outside of the top two after they were crushed 4-2 by Germany.
Portugal started strongly against the Germans, but two own goals in the space of four first-half minutes saw A Selecao eventually fall to a 4-2 defeat.
Currently third in the aptly-named 'Group of Death', a draw may still be enough to book a spot in the next round of Euro 2020.
France need only to avoid defeat to secure their place in the knockout stages of the competition.
Last time out, Antoine Griezmann spared Les Bleus' blushed and denied Hungary one of the big European Championship shocks in front a rowdy 60,000 crowd in Budapest.
Portugal and France were drawn in the same UEFA Nations League group, with Les Bleus picking up four points from their two meetings with the Portuguese. But who will come out on top tonight?
With the group stages now reaching its conclusion, our tipster Robert Mann takes a look at some of the best bets from Portugal vs France to get your teeth stuck into.
Portugal are 13/5 to win, with France priced at 23/20 to come away with the victory. A draw is priced at 21/10.
Prediction: 1-2 (7/1)
Half-Time/Full-Time: Draw/France (4/1)
Just like the Euro 2016 final between the two sides, France may just edge out Portugal to secure first in the group.
Portugal have looked unlevel in their open two games, putting three past Hungary late on, but conceding four to Germany in a crushing 4-2 defeat.
If France can exploit the Portuguese in the same manner, the world champions should win this one with ease - but it won't be easy.
Both teams boast star-studded sides and we're expecting this one to be a close end-to-end encounter, with plenty of chances for either side.
We're predicting the teams will head into the break level-pegging before France come out all guns blazing in the second half, before sinking their teeth into the jugular of the Portuguese.
And at juicy odds of 4/1, it looks far too good of a price to miss out on.
Player Assists: Bruno Fernandes to assist 1+ goals (3/1)
As Portugal look to defend their European Championship crown, they boast one of football's most in-form players in Bruno Fernandes.
With that said, it hardly looks like the return of someone about to rip up Euro 2020, no matter how talismanic they have been for their club over the last 15 months.
However, if Fernandes is set to replicate his United form, then there is no better game than tonight's against the French to do it.
Even more so, especially with a hungry Cristiano Ronaldo to feed in front of goal.
First Goalscorer: Cristiano Ronaldo (7/2)
Cristiano Ronaldo, one of the best strikers in the world, became the highest goalscorer in European Championship history just eight days ago.
And the 36-year-old was up to his usual tricks with another goal and assist against Germany, but the five-time Ballon d'Or winner had little to cheer about on Saturday.
We're backing the Portuguese maestro to draw first blood against the French tonight, especially with the Golden Boot on his mind.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
Joao Felix has shaken off discomfort in the same area and should be in contention.
Cristiano Ronaldo has never scored against France, but breaking that duck here would see him net his twentieth goal at a World Cup or Euros.
It would see the 36-year-old surpass Miroslav Klose and break yet another record in an illustrious career.
France introduced Ousmane Dembele 57 minutes in against Hungary, but had to be withdrawn after suffering a knee injury - and will now miss the remainder of the tournament.
Other than that, Didier Deschamps has no other injury or fitness concerns to work around.
Lucas Hernandez should return at left-back after Lucas Digne was given the nod last time out.
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