With no prospect of silverware this season, Liverpool are facing a dog fight to qualify for the Champions League - despite cantering to the title last year.
The Red Devils' title hopes are all but over, sitting in second, 10 points behind the neighbours in Manchester City.
However, Ole Gunnar Solskjaer would love to deal a hammer blow to Liverpool's Champions League hopes with a result on Sunday.
Here, SPORTbible takes a look at everything you need to know ahead of the big game.
Manchester United vs Liverpool is scheduled for a 4.30pm (BST) kick-off on Sunday, May 2.
It will be televised on Sky Sports Premier League and Main Event.
Sky Sports subscribers will be able to watch the match online via the Sky website or Sky Go app.
Manchester United are more than likely to finish second to Manchester City in the race for first in the Prem.
On the other hand, though, Liverpool desperately need a win to keep their hopes of Champions League qualification alive.
The result will largely depend on which United turn up - the sloppy first-half imposters or the thrilling second-half comeback kings.
But with a Champions League place hanging in the balance, Liverpool will be throwing everything they have at this.
The Reds have put together five unbeaten games on the bounce as they try to keep their place at European football's top table and should come away with the three points here.
Manchester United are 7/4 to win, with Liverpool priced at 29/20 to come away with the victory. A draw is priced at 5/2.
Odds are correct at the time of publication and are subject to change.
He could make way for Mason Greenwood, who has been in good form recently.
Defender Nathaniel Phillips could return for the Reds after overcoming a hamstring strain.
Chosen for YouChosen for You
Most Read StoriesMost Read