In the first leg, Madrid were at their very best, cementing a stamp of authority on the tie with a commanding 3-1 win in the Spanish capital.
Four days later, Zinedine Zidane witnessed his side edge out domestic rivals Barcelona, earning a result which has kept the club in the La Liga title race.
But it was during their mouth-watering clash against Liverpool last week where the Galacticos impressed the most.
Throughout the majority of the game, Jurgen Klopp's reigning English champions were outplayed by the Los Blancos with their young sensation Vinicius Junior leading the charge with two goals.
Meanwhile, Marco Asensio scored the other for Real Madrid, as Mohamed Salah netted one for the Reds, giving Liverpool a crucial away goal and something to build on at Anfield.
Liverpool have managed famous European fightbacks before, most notably when they won this competition for the fifth time on a famous night in Istanbul in 2005.
But can Klopp's Liverpool defy the odds yet again and pull off another famous night on Merseyside?
Liverpool may have left themselves with too big a mountain to climb, but write them off at your peril.
Saturday's win over Aston Villa - their first at Anfield since 16 December - may not have tipped the scales in the Reds' favour.
However, it should at least instil belief that another memorable Champions League recovery at Anfield is within their grasp.
On the other hand, Real Madrid are riding the crest of a wave at the moment, but will be put to the toughest test without three of their first-choice back four and now winger Lucas Vazquez missing.
Given how good they looked in the first leg - and how they raise their game in this competition - the 13-time champions are expected to make it through, even if they might be given a scare along the way.
Liverpool fans were left bitterly disappointed after their display against Real Madrid, with standards dropping well below what Reds supporters have seen over the past three seasons.
Prolific goalscorer Mo Salah did manage to score an away goal, which could prove vital in the return leg - a 2-0 Liverpool win would send them through to the semi-finals.
Unfortunately for Liverpool, star men Virgil Van Dijk, Joe Gomes and captain Jordan Henderson will not be back in time to sure up the defence for the second leg.
As for Real Madrid, youngster Vinicius Junior scored two cracking goals to secure a welcome lead heading into the return fixture.
Galaticos manager Zinedine Zidane will surely be confident that they can grab an away goal, meaning Liverpool will need to score three in order to have a chance of progressing.
Elsewhere, Madrid's star centre-back Raphael Varane could also return for the second leg of the quarter-final after he was ruled out of the first leg with coronavirus.
Liverpool are 10/11 to win in midweek, with Real Madrid priced at 13/5 to come away with the victory. A draw is priced at 3/1.
Odds are correct at the time of publication and are subject to change.
Liverpool's season hands on a thread as they prepare to welcome the most decorated team in the competition's history to Anfield on Wednesday night.
BT Sport will be broadcasting the highly anticipated clash from 8pm (GMT) on BT Sport 2 HD & Ultimate.
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