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While the rivalry between the two sides has diminished over the years due to Leeds' exile in the depths of English football, it's a fixture that has produced plenty of fireworks over the decades.
The Red Devils battled to a late 3-1 win over Burney at Old Trafford last time out to keep their good run of form going.
United have won their last five Premier League matches and will be hoping to extend that run and keep the pressure on Manchester City in the title race.
Leeds, meanwhile, are comfortable in mid-table and are on an impressive run themselves, unbeaten in their last five in the league with draws against Chelsea and Liverpool - as well as a famous win at Manchester City.
Marcelo Bielsa's men will be keen to gain revenge on arguably their lowest points of an otherwise excellent season when they were thrashed 6-2 at Old Trafford.
Here, SPORTbible rounds up all of the latest injury and suspension news ahead of the game.
Sunday's match will be televised live on Sky Sports' Main Event and Premier League channels, with the game kicking off at 2pm.
Sky Sports subscribers will also be available to watch the match online via the website or Sky Go app.
Manchester United have developed a happy knack of coming from behind to win matches this season, especially on the road, where they remain unbeaten in the top flight.
They have scored in the second half of their last five league matches and should do the same against a Leeds side whose high energy style could make them vulnerable to United's counterattacks.
When the teams met back in December, United scored four in the first half and two after the break and Ole Gunnar Solskjaer's men are feared to do the damage yet again.
Leeds United are 3/1 to win, with Manchester United priced at 4/5 to come away with the victory. A draw is priced at 29/10.
Odds are correct at the time of publication and are subject to change.
Meanwhile, Adam Forshaw played 84 minutes for the under-23s last week, as he bids to return following 18 months out with a hip injury.
There is also a chance that Marcus Rashford misses out, having not trained all week.
Goalkeeper Dean Henderson is also expected to keep his place in the side, despite a less than convincing display against Burnley last weekend.
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