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Realistically, Scotland need a result in London to stand a chance of qualifying for the knockout stages - but they face stiff opposition against one of the competition favourites.
And with the Three Lions among the favourites to win the competition, some might say that a final on July 11 - held at Wembley - could very well be written in the stars.
Maguire is Southgate's first pick at centre-half when fit, but Tyone Mings impressed against Croatia.
Our final session before Scotland! :muscle: pic.twitter.com/mJiypD61M8
- England (@England) June 17, 2021
With that said, it is believed Southgate will stick with the same back four on Friday, including Kieran Trippier at left-back.
Raheem Sterling justified his inclusion and suggested his patchy form with Manchester City may not carry over to the national team.
Southgate's toughest decision will be who to pick between Foden and Grealish.
Line-up: Pickford; Walker, Stones, Mings, Trippier; Phillips, Rice, Mount; Foden, Sterling, Kane.
Based on England's stellar performance against Croatia on Sunday, we think Gareth Southgate will stick with an unchanged Three Lions side.
The obvious loser is Jack Grealish, which won't please fans, but Southgate isn't one to pander to fans desires.
Line-up: Pickford; James, Stones, Mings, Shaw; Rice, Phillips, Mount; Foden, Sterling; Kane.
Alternatively, reports suggest Southgate could make changes at full back, with Reece James and Luke Shaw coming in for Walker and Trippier. The rest of the side remains the same as a win would allow England to rest players for their last game, safe in the knowledge they'll be through to the last 16.
Line-up: Pickford; Walker, Stones, Mings; Trippier, Chilwell; Rice, Mount; Foden, Sterling, Kane
Southgate's other option is to play a three at the back, which he may favour due to Maguire's injury and to match Scotland's favoured formation.
This means playing Ben Chilwell and Kieran Trippier could play as wingbacks and Walker in the back three.
Alternatively, reports suggest Luke Shaw and Reece James played in a back three during practice sessions. Given rumours suggest James and Shaw will play tonight, it's possible they could play in a back three as well.
Goalkeepers: Aaron Ramsdale, Sam Johnstone, Jordan Pickford
Defenders: Ben Chilwell, Conor Coady, Reece James, Harry Maguire, Tyrone Mings, Luke Shaw, John Stones, Ben White, Kieran Trippier, Kyle Walker
Midfielders: Jude Bellingham, Jordan Henderson, Mason Mount, Kalvin Phillips, Declan Rice
Forwards: Dominic Calvert-Lewin, Phil Foden, Jack Grealish, Harry Kane, Marcus Rashford, Bukayo Saka, Jadon Sancho, Raheem Sterling
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