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The United Kingdom showdown between two of the world's fiercest rivals will, almost certainly, be a fixture that's full of fireworks from the first to last whistle.
The Scots will travel to Wembley Stadium - the home of English football - knowing that their 23-year wait to qualify for a major tournament could be on the brink of collapse.
As for England, their impressive 1-0 win on Sunday evening against Croatia has put them as the overwhelming favourites for this game - and Gareth Southgate will be aware that another victory would all but secure a place in the last 16.
The Three Lions will be full of confidence after that opening game win and will, surely, fancy their chances of piling more misery on their old rivals.
Scotland have taken the game to England in recent years, though, and are not to be underestimated, by any means.
England and Scotland will go to war at Wembley Stadium on Friday, 18 June at 8pm.
England vs Scotland will start at 2pm (BST).
England vs Scotland will be broadcast live on ITV1 and STV, with coverage starting from 7pm.
It can also be live-streamed online via the ITV Hub and STV Hub.
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