With defence at the forefront of operations for both sides, Kristoffer Ajer joins the Bees from Celtic, while Ben White looks set to justify his £50m price tag following his move from Brighton & Hove Albion to the Gunners.
After experiencing their worst-ever start to a Premier League season in 2020/21, Arteta's side will be in the hunt of European football after missing out last term.
As for Brentford, much of the pressure will fall on the shoulders of their prolific striker in Ivan Toney, who proved vital to spurring Frank's team to promotion.
A we've waited 74 years for#BrentfordFC #BREARS pic.twitter.com/fy6mCYOluj
- Brentford FC (@BrentfordFC) August 13, 2021
Ahead of the game, our tipster Robert Mann takes a look at some of the best bets from Brentford vs Arsenal to get your teeth stuck into.
Brentford are 10/3 to win, with Arsenal priced at 17/20 to come away with the victory. A draw is priced at 5/2.
Prediction: 1-1 (11/2)
Half-Time/Full-Time: Brentford/Draw (14/1)
Brentford's first-ever Premier League fixture has the makings of a memorable night, in part because Frank's side will not fear an Arsenal side who remain in transition under Arteta.
We're backing the Bees to head into the break in the lead, before Arsenal snatch an equaliser at the death to spare their blushes.
Basically, we reckon 14/1 is far too juicy of a price to miss tonight.
Both teams to score: Yes (4/5)
Brentford are very much an unknown factor heading into the new Premier League campaign, which sees them playing in the top flight for the first time since the 1946/47 season.
As you can imagine, tonight's game is expected to be an end-to-end affair and we're backing both teams to score tonight.
Fill your boots because this one is coming in.
First Goalscorer: Ivan Toney (9/2)
Breaking the Championship goalscoring record, Toney scored a staggering 31 goals for Brentford last season.
We're backing Toney to continue that fine form in the Premier League and reckon he could very well draw first blood against the Gunners this evening.
Odds are correct at the time of publication and are, as always, subject to change.
Please gamble responsibly. For more information visit: https://www.begambleaware.org.
In a huge boost for new boys Brentford, Toney has been confirmed as fit and ready for the Premier League opener.
However, former Arsenal youngster Josh Dasilva has been ruled out with a hip problem in the Bees' only real setback.
According to The Athletic, both forwards are not available for Friday's game against Brentford as they are both unwell.
The Gunners will also be without Thomas Partey after the midfielder picked up an injury in the pre-season loss to Chelsea.
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