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The duo once shared a close relationship, with 50 Cent even playing Mayweather down to the ring for his mega-fight with Oscar De La Hoya in 2007.
However, 50 Cent and Mayweather's relationship has since soured and the pair haven't been shy to exchange a war of words with one another.
Mayweather, who will fight YouTube star Logan Paul in an exhibition fight next month, posted on Instagram a photo of himself with a new beard.
And 50 Cent, real name Curtis Jackson, didn't waste the opportunity to take a sly dig at the former four-weight world champ.
The 'Candy Shop' hitmaker implied that Mayweather received a hair implant on his face with "hair from his a*s," only to later pull the post from social media.
"LMAO," 50 Cent captioned a picture of Mayweather, before adding: "He took hair from his a*s and put it on his face. LOL WTF is really going on Champ [sic]?"
'Money' explained: "You can't hang out with me every day for years [and] then all of a sudden if I don't give you half of my company, you're like, 'You're dumb, you're stupid, you can't do this and you can't do that.'
"But if I can't do all these things, why are you hanging around with me? That's all I'm trying to add.
"If I'm such a person that doesn't know certain things, and I'm not that sharp, why you want to be around with me every day."
50 Cent's attacks on Mayweather even included a 2019 video where he challenged the boxing legend to read a full page of a Harry Potter book.
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