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'Iron' Mike shared his thoughts on the current heavyweight crop including Wilder who claimed his water was spiked before his rematch with Fury.
'The Bronze Bomber' surrendered his WBC heavyweight world title after Fury stopped him in the seventh round of their championship clash in February.
The previously-undefeated American has since said that Fury cheated and slammed former trainer Mark Breland in an extraordinary outburst.
Tyson has now had his say on Wilder's excuses, saying he should stop "internalising stuff" and "keep on fighting."
The returning boxing legend told ESPN: "When Wilder gets his head out of his butt, he's good.
"Wilder just gotta stop internalising stuff, this guy is great. Just keep on fighting.
"Fight [Fury] again. Fight him a third time. Whenever you have an opportunity to fight for the title, he should fight.
"We [as boxers] can only do this for a certain amount of time in our life, and then we can't do it anymore.
"So, we have to do it as much as we can before we end this stuff."
Tyson continued by saying Anthony Joshua, who holds the WBA (super), IBF and WBO heavyweight world titles, could learn some more.
"I don't think he's a paper champion. I just think he's a big guy - it's hard to fight being that big," he added.
"It's very difficult being that big and having to fight a smaller guy... that guy could learn some more. He could be taught some more stuff."
The 54-year-old also touched on WBC title holder Fury.
On the 'Gypsy King', he said: "I think he's very good.
"He looks like he's not intimidating, but he's really elusive, he really knows how to box, he's really smart and he's really difficult to hit and he's 7-foot, damn near. He's a monster."
Featured Image Credit: ESPN/PA
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