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The 54-year-old also slammed the undefeated boxer for believing he's better than the great Muhammed Ali ever was.
"He's very delusional," Tyson said. "Listen, if he was anywhere near that realm of great as Muhammad Ali, he'd be able to take his kids to school by himself.
"OK, he can't take his kids to school by himself, and he's talking about he's great? Greatness is not guarding yourself from the people. 'It's being accepted by the people. He can't take his kids alone to school by himself.
"He's a little scared man. He's a very small, scared man."
Tyson and Mayweather's well documented feud has often produced entertaining snippets and for many, a moment in 2015 sticks out as one of the best.
It all went down when the pair bumped into each other at a WBC convention at the Mirage Hotel & Casino in Las Vegas.
Mayweather, who was the WBC welterweight and junior middleweight champion at the time, shook hands with those on stage when 'The Baddest Man on the Planet' entered the room.
Tyson soon approached 'Money' and pretended to throw one of those famous right hands before walking away with a smirk on his face.
Check out the classic clip below.
To his credit, Mayweather didn't even flinch. He soon embraced the former heavyweight champion of the world while wearing a huge smile on his face.
Of course, this isn't the only eyebrow raising incident involving Tyson and Mayweather in years gone by.
When 'Iron Mike' was asked about the previously mentioned street fight with 'Pretty Boy' in his prime, he told GQ: "[I would] kick Floyd's a**e... there wouldn't even be no match."
The former undisputed heavyweight champ put his rivalry to one side with Mayweather when he suggested that he'd lose in a boxing fight if he were the same size as him.
He admitted: "[If] I was his size in the ring, he would outpoint me."
Mayweather, who boasts an unbeaten record of 50-0, once claimed that he was the best boxer in history and rated himself higher than the likes of Muhammad Ali and Tyson.
Do you agree with that bold statement?
Let us know in the comments.
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