The Manchester sides are in action tonight in the UEFA Champions League as United face a tough task away to Juventus, while City host Shakhtar Donetsk.
Jose Mourinho's men lost 1-0 to the Old Lady when they welcomed them to Old Trafford a fortnight ago and the bookies believe Juve will come away with the three points again tonight.
The home side are 8/13 to win the match, while United, who are missing Romelu Lukaku, Marouane Fellaini, Antonio Valencia and Diogo Dalot, are huge outsiders at 5/1.
Juventus will secure first place in the next round if they win the match and Valencia will be hoping a victory against Young Boys would move them above United into second if that is the outcome.
Former Old Trafford favourite Cristiano Ronaldo is evens to bag a goal against the Red Devils and 3/1 to open the scoring at the Juventus Stadium.
City are huge favourites against Shakhtar, and it's no surprise as the Premier League champions were 3-0 victors when they travelled to Donetsk two weeks ago.
The Ukrainians are bottom of Group F with just two points and are 19/1 to leave Manchester with the three points.
City are 4/5 to win both halves, while inform striker Sergio Aguero, who has eight goals in all competitions, is 9/4 to fire Guardiola's side into the lead.
Elsewhere, Real Madrid (3/10) continue their attempt to get their season back on track as they travel to Plzen (8/1) and German giants Bayern Munich (1/12) host AEK Athens (23/1) at the Allianz Arena.
Meanwhile, Tottenham kept their Champions League hopes alive as they came from behind to beat PSV 2-1 at Wembley last night, while Barcelona secured their place in the next round with 1-1 draw away to Inter Milan.
Liverpool lost 2-0 to Red Star in Belgrade and Napoli held PSG to a 1-1 draw. Schalke, FC Porto, Club Brugge, and Atletico Madrid also secured wins.
Remaining Champions League fixtures:
CSKA Moscow 14/5 v AS Roma 20/21
Valencia 40/85 v Young Boys 11/2
SL Benfica 6/4 v Ajax 15/8
Olympique Lyon 6/5 v Hoffenheim 2/1
Odds via BetBull.