Frank de Boer has been installed as the new Crystal Palace manager and means that there is now a full complement of managers in place at all 20 Premier League clubs.
William Hill have priced up their first manager to go market and make Rafa Benitez the 2/1 to "win" the sack race. De Boer is 50/1 to be the first to go.
"Benitez is reportedly growing increasingly frustrated and rather than being shown the door, it looks likely he could make his own way there," said William Hill spokesman Joe Crilly.
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The former Champions League winner led Newcastle to Championship promotion last season and was promised he would have funds to spend this year.
Crystal Palace Odds
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To win the League: 750/1
Relegation: 7/2
To stay up: 1/6
Top London Club
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4/5 Chelsea; 9/4 Tottenham; 11/4 Arsenal; 66/1 West Ham; 80/1 Crystal Palace; 150/1 Watford
First Premier League manager to leave
2/1 Rafa Benitez; 7/2 Slaven Bilic; 9/1 Mark Hughes; 12/1 Marco Silva; 12/1 Tony Pulis; 12/1 Craig Shakespeare; 12/1 Paul Clement; 16/1 Sean Dyche; 20/1 Chris Hughton; 20/1 David Wagner; 25/1 Antonio Conte; 25/1 Arsene Wenger; 40/1 Eddie Howe; 40/1 Jose Mourinho; 40/1 Jurgen Klopp; 40/1 Mauricio Pellegrini; 40/1 Pep Guardiola; 50/1 Frank de Boer; 50/1 Ronald Koeman; 66/1 Mauricio Pochettino